New Drugs and Regimens for Tuberculosis Disease Treatment in Children and Adolescents

Abstract After almost 30 years of relative stagnation, research over the past decade has led to remarkable advances in the treatment of both drug-susceptible (DS) and drug-resistant (DR) tuberculosis (TB) disease in children and adolescents. Compared with the previous...

How I perform hematopoietic stem cell transplantation on patients with a history of invasive fungal disease

Abstract Hematopoietic transplantation is the preferred treatment for many patients with hematologic malignancies. Some patients may develop invasive fungal diseases (IFDs) during initial chemotherapy, which need to be considered when assessing patients for...

Bone Infection Children

Update on Acute Bone and Joint Infections in Paediatrics: A Narrative Review on the Most Recent Evidence-Based Recommendations and Appropriate Antinfective Therapy Acute bone and joint infections (BJIs) in children may clinically occur as osteomyelitis (OM) or septic...

ESBL In Children

Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Children: Old Foe, Emerging Threat Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae present an ever-growing burden in the hospital and community settings, across all ages and demographics....

Cervical lymph node diseases in children

Cervical lymph node diseases in children The lymph nodes are an essential part of the body’s immune system and as such are affected in many infectious, autoimmune, metabolic and malignant diseases. The cervical lymph nodes are particularly important because they are...

Primary Immunodeficiency For ID_Imm specialist

Primary Immunodeficiency For ID_Imm specialist Purpose Patients with primary immunodeficiency diseases (PIDD) may present with recurrent infections affecting different organs, organ-specific nflammation/autoimmunity, and also increased cancer risk, particularly...

Recurrent Fever in Children

Recurrent Fever in Children Abstract: Children presenting with recurrent fever may represent a diagnostic challenge. After excluding the most common etiologies, which include the consecutive occurrence of independent uncomplicated infections, a wide range of possible...

Encephalitis Review Article NEJM

Encephalitis Review Article NEJM Encephalitis is a syndrome characterized by altered mental status and various combinations of acute fever, seizures, neurologic deficits, cerebrospinal fluid (CSF) pleocytosis, and neuroimaging and electroencephalographic (EEG)...

The Epidemiology of Invasive Meningococcal Disease in the Kingdom of Saudi Arabia: A Narrative Review with Updated Analysis

The Epidemiology of Invasive Meningococcal Disease in the Kingdom of Saudi Arabia: A Narrative Review with Updated Analysis ABSTRACT Reducing invasive meningococcal disease (IMD) through MenACWY immunization is a critical healthcare strategy in the Kingdom of Saudi...

Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old

Evaluation and Management of Well-Appearing Febrile Infants 8 to 60 Days Old This guideline addresses the evaluation and management of wellappearing, term infants, 8 to 60 days of age, with fever $38.0C. Exclusions are noted. After a commissioned evidence-based review...