Therapeutics for COVID-19

Vaccines and monoclonal antibody treatments to prevent severe coronavirus disease 2019 (COVID-19) illness were available within a year of the pandemic being declared but there remained an urgent need for therapeutics to treat patients who were not vaccinated, were...

Practice guidelines for therapeutic drug monitoring of voriconazole: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Yukihiro Hamada • Issei Tokimatsu • Hiroshige Mikamo • Masao Kimura • Masafumi Seki • Shunji Takakura • Norio Ohmagari • Yoshiko Takahashi • Kei Kasahara • Kazuaki Matsumoto • Kenji Okada • Masahiro Igarashi • Masahiro Kobayashi • Takahiro Mochizuki • Yoshifumi Nishi...

Pipeline of Novel Antifungals for Invasive Fungal Disease in Transplant Recipients: A Pediatric Perspective

Invasive fungal disease (IFD) remains a significant cause of morbidity and mortality in children undergoing transplantation. There is a growing armamentarium of novel antifungal agents recently approved for use or in late stages of clinical development. The...

A Focused Review of Epstein-Barr Virus Infections and PTLD in Pediatric Transplant Recipients: Guidance From the IPTA and ECIL Guidelines

Epstein-Barr Virus (EBV) diseases, including EBV-associated post-transplant lymphoproliferative disorder (PTLD) remain important causes of morbidity and mortality in children undergoing solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT)....

Pre-Transplantation Strategies for Infectious Disease Mitigation and Prevention

Pediatric Infectious Disease (ID) clinicians play a critical role in helping prevent and mitigate infectious risks in children peri- and post-transplantation. Prevention starts during the pre-transplant evaluation and persists throughout the solid organ transplant and...

The Microbiome and Pediatric Transplantation

The Microbiome and Pediatric Transplantation Caitlin W. Elgarten, 1,2,†, Elisa B. Margolis, 3,4,†, and Matthew S. Kelly5, 1Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, 2Department of Pediatrics, University of...

Current and Emerging Antiviral Agents in the Prevention and Treatment of Cytomegalovirus in Pediatric Transplant Recipients

Current and Emerging Antiviral Agents in the Prevention and Treatment of Cytomegalovirus in Pediatric Transplant Recipients Kristen G. Valencia Deray,1, Lara A. Danziger-Isakov,2,3 and Kevin J. Downes4,5, 1Department of Pediatrics, Division of Infectious Diseases,...

How I treat T-cell chronic active Epstein-Barr virus disease

How I treat T-cell chronic active Epstein-Barr virus disease Catherine M. Bollard1-3 and Jeffrey I. Cohen4 1Center for Cancer and Immunology Research, Children’s National Health System, Washington, DC; 2Department of Pediatrics and 3Department of Microbiology,...

White paper on antimicrobial stewardship in solid organ

White paper on antimicrobial stewardship in solid organ transplant recipients Miranda So1,2 | Jonathan Hand3 | Graeme Forrest4 | Stephanie M. Pouch5 | Helen Te6 | Monica I. Ardura7 | Rachel M. Bartash8 | Darshana M. Dadhania9 | Jeffrey Edelman10 | Dilek Ince11 |...

How I perform hematopoietic stem cell transplantation on patients with a history of invasive fungal disease

Pedro Puerta-Alcalde,1 Richard E. Champlin,2 and Dimitrios P. Kontoyiannis3 1Infectious Diseases Department, Hospital Cl´ınic Barcelona, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain; 2Department of Stem Cell Transplantation and Cellular Therapy,...